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KMID : 0363320180390061225
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Journal of Korean Oriental Internal Medicine
2018 Volume.39 No. 6 p.1225 ~ p.1243
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Schisandra Fructus Butanol Fraction Reduces Serum Total Cholesterol and Triglyceride Levels in Hyperlipidemic Mice
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Kweon Tae-Woo
Kim Young-Kyun
Kim Kyoung-Min
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Abstract
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The berries of Schisandra chinensis (Schisandra fructus) are given the name Omiza in Korean (五味子), which translates as “five flavor fruit" because they possess all five basic flavors in Korean traditional herbal medicine: salty, sweet, sour, pungent (spicy), and bitter. It is used as a remedy for many ailments: to resist infections, increase skin health, and cure insomnia, coughing, and thirst. This study was designed to investigate the effects of Schisandra fructus butanol fraction (SFB) on serum lipid levels in hyperlipidemic mice. In this experiment, effects on total cholesterol, HDL-cholesterol, and triglyceride in serum were measured. In our results, SFB did not affect weight gain in hyperlipidemic mice. Oral administration of SFB lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. Finally, administration of SFB regulated changes in gene expression which were related to cell growth and differentiation.
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KEYWORD
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Schisandra Fructus, butanol fraction, hyperlipidemia
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